Light-Sensing Proteins and Their Applications in Neuroscience and Beyond

  • Hiromu Yawo
  • Hideki Kandori
  • Amane Koizumi
  • Ryoichiro Kageyama

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1293)

About this book


This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.


Channelrhodopsin Halorhodopsin Neural circuits Optical sensors Psychiatry Visual prosthesis Optogenetics rhodopsin Biological light sensor Neuroscience neurobiology cell biology optoelectronics

Editors and affiliations

  • Hiromu Yawo
    • 1
  • Hideki Kandori
    • 2
  • Amane Koizumi
    • 3
  • Ryoichiro Kageyama
    • 4
  1. 1.The Institute for Solid State PhysicsThe University of TokyoKashiwaJapan
  2. 2.OptoBioTechnology Research CenterNagoya Institute of TechnologyNagoyaJapan
  3. 3.National Institutes of Natural SciencesTokyoJapan
  4. 4.Institute for Frontier Life and Medical SciencesKyoto UniversityKyotoJapan

Bibliographic information